Purpose-built, high-precision MRD testing
Ultrasensitive ctDNA detection
Learn how we support clinicians and biopharma in our mission by providing ultrasensitive MRD testing for informed clinical management and therapeutic development.

High precision
Exceptional sensitivity
Minimal residual disease (MRD) testing demands high-sensitivity circulating tumor DNA (ctDNA) detection. Haystack MRD is a tumor-informed, next-generation MRD test that detects ultralow levels of ctDNA to uncover residual disease in patients with solid tumors.
Neoadjuvant response
Measure ctDNA in the neoadjuvant setting to assess treatment response.
Residual disease detection
Exceptional sensitivity and specificity for informed adjuvant therapy decision-making.
Treatment response assessment
Follow patient’s response to adjuvant therapy to greater depths and with better sensitivity than traditional methods.
Recurrence surveillance
Limit of detection of 0.0006% means that patients who recur may be identified earlier than with traditional methods.
Purpose built
The Haystack MRD difference
MRD testing demands high-sensitivity ctDNA detection. Haystack MRD is a tumor-informed, next-generation MRD test that detects ultralow levels of ctDNA to uncover residual disease after definitive surgery.
- Innovation and leadership
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A track record of Innovation and leadership
Haystack MRD is the product of more than 20 years of pioneering work in liquid biopsy technologies and is purpose-built for ultrasensitive ctDNA detection.Haystack MRD has been developed on the foundational work of cancer genomics pioneers, whose discoveries have transformed clinical practice for cancer patients. - Confident MRD results
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Confident MRD results
Haystack MRD’s technology enables ultrasensitive ctDNA testing with the ability to detect 95% of cases at 0.0006% tumor fraction. With an exceptionally low limit of detection, you can uncover the insights you need to help make confident treatment decisions. -
- The power of Quest
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Prioritized patient access The power of Quest
End-to-end reliability powered by Quest Diagnostics credentialed staff, labs, logistics, service, reporting, test menu, and technology.Screening
Hereditary genetic risk and colorectal clinical solutionsDiagnosis
Subspecialized pathology solutionsPrognosis
Molecular testingTreatment selection
Solid tumor NGS, heme NGS, hereditary cancer NGSMonitoring
Therapy impact and routine testing post-treatment

A track record of Innovation and leadership
Haystack MRD is the product of more than 20 years of pioneering work in liquid biopsy technologies and is purpose-built for ultrasensitive ctDNA detection.
Haystack MRD has been developed on the foundational work of cancer genomics pioneers, whose discoveries have transformed clinical practice for cancer patients.
Confident MRD results
Haystack MRD’s technology enables ultrasensitive ctDNA testing with the ability to detect 95% of cases at 0.0006% tumor fraction. With an exceptionally low limit of detection, you can uncover the insights you need to help make confident treatment decisions.

Prioritized patient access The power of Quest
End-to-end reliability powered by Quest Diagnostics credentialed staff, labs, logistics, service, reporting, test menu, and technology.
Screening
Hereditary genetic risk and colorectal clinical solutions
Diagnosis
Subspecialized pathology solutions
Prognosis
Molecular testing
Treatment selection
Solid tumor NGS, heme NGS, hereditary cancer NGS
Monitoring
Therapy impact and routine testing post-treatment
Industry upates
Recent news
Find out what’s happening at Haystack Oncology and stay up-to-date with industry news.

Learn about Haystack MRD™ at ASCO 2025
Haystack MRD™ is proud to be part of the American Society of Clinical Oncology (ASCO) Annual Meeting, where oncology innovation takes center stage. Join us at booth #11069 to explore how our ctDNA-based assay delivers confidence in detecting even the smallest traces of residual disease.

Haystack MRD™ by Quest Diagnostics® at SSO 2025
We invite you to connect with us at SSO 2025 to learn how Haystack MRD can help guide treatment decisions with confidence. From the perioperative setting to recurrence surveillance, Haystack MRD tracks ctDNA across the treatment management journey—empowering oncologists to make informed, timely treatment decisions.
