Gain critical insights with confident MRD testing

Haystack MRD is a tumor-informed test, personalized for each patient. A test panel targeting up to 50 variants is developed to detect ctDNA in a blood sample. The test can then be performed whenever needed to monitor treatment response and detect residual or recurrent disease throughout the patient’s care journey.

  • Exceptional accuracy
  • Tumor-informed
  • Personalized
  • Track 50 variants
  • Baseline and Monitoring

Purpose-built

Enhanced performance for confidence in your MRD results

Our advanced tumor-informed minimal residual disease (MRD) test detects circulating tumor DNA (ctDNA) in blood using proprietary technology that double-checks each variant to eliminate sequencing noise. This ensures that whether ctDNA is detected or not, you can trust the results to help you more fully understand your patient’s disease status, delivering the confidence needed when answering patients’ most pressing questions.

Did my treatment work?

Go beyond standard risk assessment for adjuvant chemotherapy to help guide the right treatment for the right person at the right time.

Do I need additional therapy?

Track ctDNA levels in real time to monitor treatment response.

Is the cancer coming back?

95% limit of detection of 0.0006% tumor fraction to help identify recurrence earlier than traditional methods so you can intervene sooner.

This graphic is a theoretical representation only

High precision

Looking deeper to give you clearer answers

Designed to give you the best chance of getting the right answer the first time, Haystack MRD’s ultradeep sequencing reads each molecule up to 1 million times, delivering confident results to help guide critical treatment decisions.

Confidence to see more

Haystack MRD can detect 95% of cases at 0.0006% tumor fraction,1 providing better clarity by looking deeper. The importance of advanced ctDNA testing was shown in our Early Experience program, where 30% of Haystack MRD-positive (disease detected) cases had ctDNA levels in the ultrasensitive range.1 Some MRD tests might not have readily detected ctDNA at those levels, risking delayed intervention.

Confidence that what you see is real

With zero false-positive results, Haystack MRD boasts analytical specificity of 100%,2 which is underscored by published clinical data. In a groundbreaking immunotherapy study, all patients whose tumors disappeared were Haystack MRD-negative by the end of treatment.3 In the DYNAMIC study—powered by an earlier version of Haystack technology—all cases without recurrence were ctDNA-negative after treatment (no false positives).4

High-precision

Confidence in your MRD results from a test driven by technical and clinical rigor

With ctDNA detection technology backed by 2 NEJM-published studies—one using an earlier version and one using our current technology—Haystack MRD demonstrates both clinical impact and credibility.

Mature 5 year data The DYNAMIC TRIAL

Using an earlier generation of Haystack technology, the DYNAMIC trial became the first interventional study to show that ctDNA can guide adjuvant therapy decisions, with results validated after 5 years of follow-up.

Immunotherapy treatment response

In a landmark study, many patients with mismatch repair–deficient (dMMR) cancers were effectively treated with immunotherapy alone, without surgery, chemotherapy, or radiation. Haystack MRD served as a real-time method to track how patients respond to treatment, identifying response to therapy earlier than traditional imaging methods.

Get in touch

Contact us to order Haystack MRD

Have questions? Looking to order Haystack MRD? Let our exceptional MRD detection capabilities and team of global experts support your clinical cancer research and therapeutic development efforts.

1. Data on file. Haystack Oncology; 2024-2025.
2. Prathapam R, Champion K, Blakely K, et al. J Mol Diagn. 2024;26(11):S100; doi:10.1016/S1525-1578(24)00232-0
3. Cercek A, Foote MB, Rousseau B, et al. N Engl J Med. 2025;392(23):2297-2308. doi:10.1056/NEJMoa2404512
4. Tie J, Wang Y, Lo S, Gibbs, P. Nat Med. 2025;31(5):1509-1518

Patient access application mailing instructions

Haystack MRD
C/O Quest Diagnostics
2501 S State Hwy 121, Suite 1100
Lewisville, TX 75067

Para solicitar ayuda financiera, complete la solicitud y firme la autocertificación.

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Visit Johns Hopkins School of Medicine to learn more.
Visit Johns Hopkins School of Medicine to learn more.
Visit Johns Hopkins School of Medicine to learn more.